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Energetic cost of biosynthesis is a missing link between growth and longevity in mammals

6 May 2024

Abstract excerpt

The comparative studies of aging have established a negative correlation between Gompertz postnatal growth constant and maximum lifespan across mammalian species, but the underlying physiological mechanism remains unclear. This study shows that the Gompertz growth constant can be decomposed into two energetic components, mass-specific metabolic rate and the energetic cost of biosynthesis, and that after...

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PMID: 38709928
DOI: 10.1073/pnas.2315921121

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