Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

X-linked genetic associations in sporadic thoracic aortic dissection.

American journal of medical genetics. Part A - 1 Sept 2024

Musfee Fadi I, Jun Goo, Mitchell Laura E, Chen Han, Guo Dongchuan, Prakash Siddharth K, Adkar Shaunak Sanjay, Grove Megan L, Choi Ryan Bohyun, Klarin Derek, Boerwinkle Eric, Milewicz Dianna M

Abstract excerpt

The male predominance in sporadic thoracic aortic aneurysm and dissection (TAD) suggests that the X chromosome contributes to TAD, but this has not been tested. We investigated whether X-linked variation-common (minor allele frequency [MAF] ≥0.01) and rare (MAF <0.01)-was associated with sporadic TAD in three cohorts of European descent (Discovery: 364 cases, 874 controls; Replication: 516 cases, 440,131...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aortic Aneurysm, Thoracic
Share to Case-Control Studies

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Chromosomes, Human, X

Share to Cohort Studies

Share to Gene Frequency

Share to Genes, X-Linked

Share to Genetic Association Studies

Share to Genome-Wide Association Study

Source

Open in PubMed Open full text

Identifiers

PMID: 38688863
DOI: 10.1002/ajmg.a.63644
PMCID: PMC11315632

Genes

MAF
SPANXN1
ZNF182

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

X-linked genetic associations in sporadic thoracic aortic dissection.PMID 38688863Read ↗

Identification of COL3A1 variants associated with sporadic thoracic aortic dissection: a case-control study.Semantic proximity Read ↗

Analysis of Genetic Contribution to Thoracic Aortic Aneurysm or Dissection in a Prospective Cohort of Familial and Sporadic Cases in East ChinaSemantic proximity Read ↗

Targeted genetic analysis in a large cohort of familial and sporadic cases of aneurysm or dissection of the thoracic aorta.Semantic proximity Read ↗

Differential Analysis of Pathogenic Variants in Thoracic Aortic Aneurysm and Dissection at Different Ages.Semantic proximity Read ↗

Genome-wide association study identifies a susceptibility locus for thoracic aortic aneurysms and aortic dissections spanning FBN1 at 15q21.1.Semantic proximity Read ↗

Association of polymorphisms in FBN1, MYH11, and TGF-β signaling-related genes with susceptibility of sporadic thoracic aortic aneurysm and dissection in the Zhejiang Han populationSemantic proximity Read ↗

Identification of Variants of Uncertain Significance in the Genes Associated with Thoracic Aortic Disease in Russian Patients with Nonsyndromic Sporadic Subtypes of the Disorder.Semantic proximity Read ↗

Novel Genetic Variants of Thoracic Aortic Aneurysm and Dissection: Evidence from a Japanese Community-Based CohortSemantic proximity Read ↗

Wide mutation spectrum and frequent variant Ala27Thr of FBN1 identified in a large cohort of Chinese patients with sporadic TAAD.Semantic proximity Read ↗

Recurrent Rare Genomic Copy Number Variants and Bicuspid Aortic Valve Are Enriched in Early Onset Thoracic Aortic Aneurysms and Dissections.Semantic proximity Read ↗

Spontaneous coronary artery dissection is infrequent in individuals with heritable thoracic aortic disease despite partially shared genetic susceptibility.Semantic proximity Read ↗

Genetic architecture of thoracic aortic dissection in the female population.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.