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Article

Novel variant in Nudix hydrolase 15 gene influences 6-mercaptopurine toxicity in childhood acute lymphoblastic leukemia patients.

Pharmacogenetics and genomics - 1 Jul 2024

Sabirova Zarina, Mahnoor Shazia, Lasfar Dina, Gagné Vincent, Théorêt Yves, Leclerc Jean Marie, Laverdière Caroline, Sinnett Daniel, Tran Thai-Hoa, Krajinovic Maja

Abstract excerpt

Acute lymphoblastic leukemia (ALL) is the most frequent pediatric cancer. 6-Mercaptopurine (6-MP) is a key component of ALL treatment. Its use, however, is also associated with adverse drug reactions, particularly myelosuppression. Thiopurine S-methyltransferase (TPMT) and, more recently, Nudix hydrolase 15 (NUDT15) deficiency, due to no-function variants in their respective genes, are well known for their role...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 38682355
DOI: 10.1097/FPC.0000000000000533

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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