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TTN Mutation in Endometrial Endometrioid Carcinoma Is Associated with Poor Clinical Outcomes and High Tumor Mutation Burden.

Cancer investigation - 1 Apr 2024

Li Lihong, Yue Pinli, Zhu Jiarun, Li Luyuan, Wang Kaipeng, Yuan Guangwen, Song Yan

Abstract excerpt

Endometrioid endometrial carcinoma (EEC) stands as a prevalent gynecologic malignancy in developed regions. However, predicting relapse cases remains challenging, necessitating the identification of a novel biomarker for EEC relapse. The assessment of tumor mutational burden (TMB) is pivotal for immunotherapy in EEC patients. However, both whole-exome sequencing (WES) and targeted sequencing encountered...

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PMID: 38666471
DOI: 10.1080/07357907.2024.2334249

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