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Denitrogenative Alkylation of K-Ras(G12D) Inhibits Oncogenic Signaling in Cancer Cells.

Journal of the American Chemical Society - 16 Jul 2025

Zheng Qinheng, Shokat Kevan M

Abstract excerpt

Pancreatic ductal adenocarcinoma (PDAC) is the most lethal common cancer. More than 90% of PDAC tumors are caused by KRAS mutations, with the majority expressing the K-Ras(G12D) oncoprotein. Despite extensive drug discovery efforts across academia and industry, there are no approved drugs directly targeting K-Ras(G12D) in a mutant-selective manner. We report a series of α-diazoacetamide compounds that form...

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PMID: 40587607
DOI: 10.1021/jacs.5c06745
PMCID: PMC12272675

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KRAS

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Denitrogenative Alkylation of K-Ras(G12D) Inhibits Oncogenic Signaling in Cancer Cells.PMID 40587607Read ↗

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