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Article

Unraveling the molecular relevance of brain phenotypes: A comparative analysis of null models and test statistics.

NeuroImage - 1 Jun 2024

Cao Zhipeng, Zhan Guilai, Qin Jinmei, Cupertino Renata B, Ottino-Gonzalez Jonatan, Murphy Alistair, Pancholi Devarshi, Hahn Sage, Yuan Dekang, Callas Peter, Mackey Scott, Garavan Hugh

Abstract excerpt

Correlating transcriptional profiles with imaging-derived phenotypes has the potential to reveal possible molecular architectures associated with cognitive functions, brain development and disorders. Competitive null models built by resampling genes and self-contained null models built by spinning brain regions, along with varying test statistics, have been used to determine the significance of transcriptional...

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Identifiers

PMID: 38648869
DOI: 10.1016/j.neuroimage.2024.120622
PMCID: PMC11132826

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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