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Article

Phototoxicity avoidance is a potential therapeutic approach for retinal dystrophy caused by EYS dysfunction.

JCI insight - 22 Apr 2024

Otsuka Yuki, Imamura Keiko, Oishi Akio, Asakawa Kazuhide, Kondo Takayuki, Nakai Risako, Suga Mika, Inoue Ikuyo, Sagara Yukako, Tsukita Kayoko, Teranaka Kaori, Nishimura Yu, Watanabe Akira, Umeyama Kazuhiro, Okushima Nanako, Mitani Kohnosuke, Nagashima Hiroshi, Kawakami Koichi, Muguruma Keiko, Tsujikawa Akitaka, Inoue Haruhisa

Abstract excerpt

Inherited retinal dystrophies (IRDs) are progressive diseases leading to vision loss. Mutation in the eyes shut homolog (EYS) gene is one of the most frequent causes of IRD. However, the mechanism of photoreceptor cell degeneration by mutant EYS has not been fully elucidated. Here, we generated retinal organoids from induced pluripotent stem cells (iPSCs) derived from patients with EYS-associated retinal...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 38646933
DOI: 10.1172/jci.insight.174179
PMCID: PMC11141876

Genes

EYS
GRK7

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Phototoxicity avoidance is a potential therapeutic approach for retinal dystrophy caused by EYS dysfunction.PMID 38646933Read ↗

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