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Article

Eyes shut homolog is important for the maintenance of photoreceptor morphology and visual function in zebrafish.

PloS one - 1 Jan 2018

Messchaert Muriël, Dona Margo, Broekman Sanne, Peters Theo A, Corral-Serrano Julio C, Slijkerman Ralph W N, van Wijk Erwin, Collin Rob W J

Abstract excerpt

Mutations in eyes shut homolog (EYS), a gene predominantly expressed in the photoreceptor cells of the retina, are among the most frequent causes of autosomal recessive (ar) retinitis pigmentosa (RP), a progressive retinal disorder. Due to the absence of EYS in several rodent species and its retina-specific expression, still little is known about the exact function of EYS and the pathogenic mechanism underlying...

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Source

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Identifiers

PMID: 30052645
DOI: 10.1371/journal.pone.0200789
PMCID: PMC6063403

Genes

EYS
EGF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

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Eyes shut homolog is important for the maintenance of photoreceptor morphology and visual function in zebrafish.PMID 30052645Read ↗

The medaka mutant deficient in eyes shut homolog exhibits opsin transport defects and enhanced autophagy in retinal photoreceptors.Semantic proximity Read ↗

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Identification of Novel EYS Mutations by Targeted Sequencing Analysis.Semantic proximity Read ↗

EYS, encoding an ortholog of Drosophila spacemaker, is mutated in autosomal recessive retinitis pigmentosa.Semantic proximity Read ↗

Ablation of EYS in zebrafish causes mislocalisation of outer segment proteins, F-actin disruption and cone-rod dystrophySemantic proximity Read ↗

Shutdown corner, a large deletion mutant isolated from a haploid mutagenesis screen in zebrafish.Semantic proximity Read ↗

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