Article
Mutation of cGMP phosphodiesterase 6alpha'-subunit gene causes progressive degeneration of cone photoreceptors in zebrafish.
Mechanisms of development - 1 Jan 2000
Nishiwaki Yuko, Komori Atsuko, Sagara Hiroshi, Suzuki Emiko, Manabe Tomonori, Hosoya Toshihiko, Nojima Yasuhiro, Wada Hironori, Tanaka Hideomi, Okamoto Hitoshi, Masai Ichiro
Abstract excerpt
In mammals, the blockade of the phototransduction cascade causes loss of vision and, in some cases, degeneration of photoreceptors. However, the molecular mechanisms that link phototransduction with photoreceptor degeneration remain to be elucidated. Here, we report that a mutation in the gene encoding a central effector of the phototransduction cascade, cGMP phosphodiesterase 6alpha'-subunit (PDE6alpha'),...
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