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Article

Poor prognosis of SRSF2 gene mutations in patients treated with VEN-AZA for newly diagnosed acute myeloid leukemia.

Leukemia research - 1 Jun 2024

Berton Guillaume, Sedaki Bochra, Collomb Erwann, Benachour Sami, Loschi Michael, Mohty Bilal, Saillard Colombe, Hicheri Yosr, Rouzaud Camille, Maisano Valerio, Villetard Ferdinand, Corda Evelyne D 'Incan, Charbonnier Aude, Rey Jerome, Hospital Marie-Anne, Ittel Antoine, Abbou Norman, Fanciullino Raphaelle, Dadone-Montaudié Bérengère, Vey Norbert, Venton Geoffroy, Cluzeau Thomas, Alary Anne-Sophie, Garciaz Sylvain

Abstract excerpt

Mutations in spliceosome genes (SRSF2, SF3B1, U2AF1, ZRSR2) correlate with inferior outcomes in patients treated with intensive chemotherapy for Acute Myeloid Leukemia. However, their prognostic impact in patients treated with less intensive protocols is not well known. This study aimed to evaluate the impact of Spliceosome mutations in patients treated with Venetoclax and Azacitidine for newly diagnosed AML. 117...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 38636413
DOI: 10.1016/j.leukres.2024.107500

Genes

SRSF2
NRAS
SF3B1
U2AF1
ZRSR2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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