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Article

Association of Germline Genetic Testing Results With Locoregional and Systemic Therapy in Patients With Breast Cancer.

JAMA oncology - 1 Apr 2020

Kurian Allison W, Ward Kevin C, Abrahamse Paul, Hamilton Ann S, Deapen Dennis, Morrow Monica, Jagsi Reshma, Katz Steven J

Abstract excerpt

Importance: The increasing use of germline genetic testing may have unintended consequences on treatment. Little is known about how women with pathogenic variants in cancer susceptibility genes are treated for breast cancer. Objective: To determine the association of germline genetic testing results with locoregional and systemic therapy use in women diagnosed with breast cancer. Design, Setting, and...

Topics

Aged
BRCA1 Protein
BRCA2 Protein
Breast Neoplasms
Female
Genetic Predisposition to Disease
Genetic Testing
Germ-Line Mutation
Humans
Mastectomy, Segmental
Middle Aged

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Neoadjuvant Therapy

Neoplasm Recurrence, Local

Receptor, ErbB-2

Source

Open in PubMed Open full text

Identifiers

PMID: 32027353
DOI: 10.1001/jamaoncol.2019.6400
PMCID: PMC7042883

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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