Article
Lipoarabinomannan modification as a source of phenotypic heterogeneity in host-adapted Mycobacterium abscessus isolates.
Proceedings of the National Academy of Sciences of the United States of America - 23 Apr 2024
De Kavita, Belardinelli Juan M, Pandurangan Arun Prasad, Ehianeta Teddy, Lian Elena, Palčeková Zuzana, Lam Ha, Gonzalez-Juarrero Mercedes, Bryant Josephine M, Blundell Tom L, Parkhill Julian, Floto R Andres, Lowary Todd L, Wheat William H, Jackson Mary
Abstract excerpt
Mycobacterium abscessus is increasingly recognized as the causative agent of chronic pulmonary infections in humans. One of the genes found to be under strong evolutionary pressure during adaptation of M. abscessus to the human lung is embC which encodes an arabinosyltransferase required for the biosynthesis of the cell envelope lipoglycan, lipoarabinomannan (LAM). To assess the impact of patient-derived embC...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.