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FGFR1 fusions as a novel molecular driver in rhabdomyosarcoma

1 Apr 2024

Abstract excerpt

The wide application of RNA sequencing in clinical practice has allowed the discovery of novel fusion genes, which have contributed to a refined molecular classification of rhabdomyosarcoma (RMS). Most fusions in RMS result in aberrant transcription factors, such as PAX3/7::FOXO1 in alveolar RMS (ARMS) and fusions involving VGLL2 or NCOA2 in infantile spindle cell RMS. However, recurrent fusions driving oncogenic...

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PMID: 38607246
DOI: 10.1002/gcc.23232

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