Article
Recombinational exchange of M-fibril and T-pilus genes generates extensive cell surface diversity in the global group A Streptococcus population.
mBio - 8 May 2024
Bessen Debra E, Beall Bernard W, Hayes Andrew, Huang Weihua, DiChiara Jeanne M, Velusamy Srinivasan, Tettelin Hervé, Jolley Keith A, Fallon John T, Chochua Sopio, Alobaidallah Mosaed S A, Higgs Charlie, Barnett Timothy C, Steemson John T, Proft Thomas, Davies Mark R
Abstract excerpt
Among genes present in all group A streptococci (GAS), those encoding M-fibril and T-pilus proteins display the highest levels of sequence diversity, giving rise to the two primary serological typing schemes historically used to define strain. A new genotyping scheme for the pilin adhesin and backbone genes is developed and, when combined with emm typing, provides an account of the global GAS strain population....
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