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Article

Genomic DNA methylation distinguishes subtypes of human focal cortical dysplasia

10 May 2019

Abstract excerpt

OBJECTIVES: Focal cortical dysplasia (FCD) is a major cause of drug-resistant focal epilepsy in children, and the clinicopathological classification remains a challenging issue in daily practice. With the recent progress in DNA methylation-based classification of human brain tumors we examined whether genomic DNA methylation and gene expression analysis can be used to also distinguish human FCD subtypes. METHODS:...

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PMID: 31074842
DOI: 10.1111/epi.14934

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