Pangenome databases improve host removal and mycobacteria classification from clinical metagenomic data

Abstract excerpt

BACKGROUND: Culture-free real-time sequencing of clinical metagenomic samples promises both rapid pathogen detection and antimicrobial resistance profiling. However, this approach introduces the risk of patient DNA leakage. To mitigate this risk, we need near-comprehensive removal of human DNA sequences at the point of sequencing, typically involving the use of resource-constrained devices. Existing benchmarks...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Genomics and Phylogenetic Studies
• Share to Mycobacterium research and diagnosis
• Share to Tuberculosis Research and Epidemiology