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Article

Population-specific variations in KCNH2 predispose patients to delayed ventricular repolarization upon dihydroartemisinin-piperaquine therapy.

Antimicrobial agents and chemotherapy - 2 May 2024

Camara Mahamadou D, Zhou Yitian, Dara Antoine, Tékété Mamadou M, Nóbrega de Sousa Taís, Sissoko Sékou, Dembélé Laurent, Ouologuem Nouhoun, Hamidou Togo Amadou, Alhousseini Mohamed L, Fofana Bakary, Sagara Issaka, Djimde Abdoulaye A, Gil Pedro J, Lauschke Volker M

Abstract excerpt

Dihydroartemisinin-piperaquine is efficacious for the treatment of uncomplicated malaria and its use is increasing globally. Despite the positive results in fighting malaria, inhibition of the Kv11.1 channel (hERG; encoded by the KCNH2 gene) by piperaquine has raised concerns about cardiac safety. Whether genetic factors could modulate the risk of piperaquine-mediated QT prolongations remained unclear. Here, we...

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Identifiers

PMID: 38546223
DOI: 10.1128/aac.01390-23
PMCID: PMC11064487

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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