Article
IgG from Dermatophagoides pteronyssinus (Der p)-atopic individuals modulates non-atopic thymic B cell phenotype (alfa-4/beta-7) and cytokine production (IFN-γ, IL-9, and IL-10) with direct membrane interaction.
Scientific reports - 27 Mar 2024
de-Apoena Reche Daniela Terra, Machado Nicolle Rakanidis, Fagundes Beatriz Oliveira, Bergamasco Isabella Siuffi, de Sousa Thamires Rodrigues, do Nascimento Lais Alves, Cunha Fernando Roberto Machado, de-Oliveira Marilia Garcia, da-Ressureição Sgnotto Fábio, França Carolina Nunes, Victor Jefferson Russo
Abstract excerpt
Studies about thymic B cells are scarce in the literature, but it was suggested that they can exert modulatory and regulatory functions on the immune system. Thymic B cells can play some role in regulating the most frequent allergic background worldwide, the atopy induced by the mite Dermatophagoides pteronyssinus (Der p). Here, we aimed to evaluate if the polyclonal IgG repertoire produced by Der p-atopic...
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