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Single nuclei transcriptomics of the in situ human limbal stem cell niche

21 Mar 2024

Abstract excerpt

The corneal epithelium acts as a barrier to pathogens entering the eye; corneal epithelial cells are continuously renewed by uni-potent, quiescent limbal stem cells (LSCs) located at the limbus, where the cornea transitions to conjunctiva. There has yet to be a consensus on LSC markers and their transcriptome profile is not fully understood, which may be due to using cadaveric tissue without an intact stem cell...

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PMID: 38514716
DOI: 10.1038/s41598-024-57242-4

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