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Article

DMC1 mutation that causes human non-obstructive azoospermia and premature ovarian insufficiency identified by whole-exome sequencing

13 Jan 2018

Abstract excerpt

Background The genetic causes of the majority of male and female infertility caused by human non-obstructive azoospermia (NOA) and premature ovarian insufficiency (POI) with meiotic arrest are unknown. Objective To identify the genetic cause of NOA and POI in two affected members from a consanguineous Chinese family. Methods We performed whole-exome sequencing of DNA from both affected patients. The identified...

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PMID: 29331980
DOI: 10.1136/jmedgenet-2017-104992

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