Article
Azacitidine combined with venetoclax alleviates AML-MR with TP53 mutation in SDS: a case report and literature review.
Anti-cancer drugs - 1 Jul 2024
Ma Cuiping, Lang Haiyan, Chen Yuhan, Yang Lu, Wang Chong, Han Lizhen, Chen Xinyi, Ma Wei
Abstract excerpt
Shwachman-Diamond syndrome (SDS) is an autosomal recessive genetic disease, which is prone to transform into myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML). TP53 mutation is a driving factor involved in the transformation of SDS into MDS/AML, and in the evolution of MDS to AML. Allogeneic hematopoietic stem cell transplantation (Allo-HSCT) is the only curable approach, however, challenge remains...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.