Decitabine with etoposide is effective in TP53 mutated myeloid tumors via overcoming differentiation block

Abstract excerpt

Myelodysplastic syndromes (MDS) and acute myeloid leukemia (AML) represent a clonal disorder of myeloid hematopoiesis, mostly characterized by unfavorable mutations or karyotypes, advanced age, and poor prognosis [ 1 ]. Patients with TP53 mutations in high-risk MDS and AML typically face a worse prognosis [ 2 , 3 ]. Current therapeutic strategies for these patients include hypomethylating agents (HMAs),...

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