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Hematopoietic Stem Cells Undergo Differentiation State Reprogramming to Overcome Venetoclax Sensitivity in Patients with Myelodysplastic Syndromes

2023-09-28

Abstract excerpt

<h4>ABSTRACT</h4> While the molecular mechanisms of acute myeloid leukemia failure to venetoclax-based therapy have been recently clarified, the mechanisms whereby patients with myelodysplastic syndromes (MDS) acquire secondary resistance to venetoclax after an initial response remain to be elucidated. Here, we show for the first time that MDS hematopoietic stem cells (HSCs) can undergo hierarchical differentiati...

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Literature Corpus work
72d5c67d-c93b-581b-8e06-56eef1bbf421
DOI
10.1101/2023.09.25.559439
Open publication

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Hematopoietic Stem Cells Undergo Differentiation State Reprogramming to Overcome Venetoclax Sensitivity in Patients with Myelodysplastic SyndromesDOI 10.1101/2023.09.25.559439
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