Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

No significant sex differences in incidence or phenotype for the SMNΔ7 mouse model of spinal muscular atrophy.

Neuromuscular disorders : NMD - 1 Apr 2024

Cottam Nicholas C, Harrington Melissa A, Schork Pamela M, Sun Jianli

Abstract excerpt

Spinal muscular atrophy (SMA) is an autosomal recessive disease that affects 1 out of every 6,000-10,000 individuals at birth, making it the leading genetic cause of infant mortality. In recent years, reports of sex differences in SMA patients have become noticeable. The SMNΔ7 mouse model is commonly used to investigate pathologies and treatments in SMA. However, studies on sex as a contributing biological...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Disease Models, Animal
Share to Incidence
Share to Mice

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Muscular Atrophy, Spinal

Share to Phenotype

Share to Sex Characteristics

Share to Survival of Motor Neuron 1 Protein

Source

Open in PubMed Open full text

Identifiers

PMID: 38493520
DOI: 10.1016/j.nmd.2024.03.002
PMCID: PMC11031329

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

No significant sex differences in incidence or phenotype for the SMNΔ7 mouse model of spinal muscular atrophy.PMID 38493520Read ↗

Abnormal motor phenotype in the SMNDelta7 mouse model of spinal muscular atrophy.Semantic proximity Read ↗

Neuromuscular defects and breathing disorders in a new mouse model of spinal muscular atrophy.Semantic proximity Read ↗

TIA1 is a gender-specific disease modifier of a mild mouse model of spinal muscular atrophy.Semantic proximity Read ↗

Prediction of death in the SMNΔ7 mouse model of spinal muscular atrophy: insight into disease stage and progression.Semantic proximity Read ↗

Gender Effects on the Clinical Phenotype in Japanese Patients with Spinal Muscular Atrophy.Semantic proximity Read ↗

Molecular and phenotypic reassessment of an infrequently used mouse model for spinal muscular atrophy.Semantic proximity Read ↗

PTEN depletion decreases disease severity and modestly prolongs survival in a mouse model of spinal muscular atrophy.Semantic proximity Read ↗

Immune dysregulation may contribute to disease pathogenesis in spinal muscular atrophy miceSemantic proximity Read ↗

Animal models of spinal muscular atrophySemantic proximity Read ↗

Very severe spinal muscular atrophy (SMA type 0): an expanding clinical phenotype.Semantic proximity Read ↗

Spinal Muscular Atrophy (SMA) Subtype Concordance in Siblings: Findings From the Cure SMA Cohort.Semantic proximity Read ↗

Phenotype modifiers of spinal muscular atrophy: the number of SMN2 gene copies, deletion in the NAIP gene and probably gender influence the course of the disease.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.