Article
Characterization of Omicron BA.4.6, XBB, and BQ.1.1 subvariants in hamsters.
Communications biology - 15 Mar 2024
Halfmann Peter J, Iwatsuki-Horimoto Kiyoko, Kuroda Makoto, Hirata Yuichiro, Yamayoshi Seiya, Iida Shun, Uraki Ryuta, Ito Mutsumi, Ueki Hiroshi, Furusawa Yuri, Sakai-Tagawa Yuko, Kiso Maki, Armbrust Tammy, Spyra Sam, Maeda Ken, Wang Zhongde, Imai Masaki, Suzuki Tadaki, Kawaoka Yoshihiro
Abstract excerpt
During the Omicron wave, previous variants such as BA.2, BA.4, and BA.5 were replaced by newer variants with additional mutations in the spike protein. These variants, BA.4.6, BQ.1.1, and XBB, have spread in different countries with different degrees of success. Here, we evaluated the replicative ability and pathogenicity of BA.4.6, BQ1.1, and XBB clinical isolates in male Syrian hamsters. Although we found no...
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