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Polymorphism in the leucine-rich repeats of TLR7 in different breeds of chicken and in silico analysis of its effect on TLR7 structure and function.

Gene - 20 Jun 2024

Kaliappan Abinaya, Ramakrishnan Saravanan, Thomas Prasad, Verma Surya Kant, Panwar Khushboo, Singh Mithilesh, Dey Sohini, Mohan Chellappa Madhan

Abstract excerpt

Chicken toll-like receptor 7 (chTLR7) is a viral sensing pattern recognition receptor and detects ssRNA. The ligand binding site comprises leucine-rich repeats (LRRs) located in the ectodomain of chTLR7. Hence, any polymorphism in the binding site would modify its functional interaction with the ligand, resulting in varied strength of immune response. This study first aimed to compare the single nucleotide...

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Identifiers

PMID: 38490513
DOI: 10.1016/j.gene.2024.148373

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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