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Article

Gene Polymorphisms of NLRP3 Associated With Plasma Levels of 4β-Hydroxycholesterol, an Endogenous Marker of CYP3A Activity, in Patients With Asthma.

Clinical pharmacology and therapeutics - 1 Jul 2024

Hirai Keita, Kimura Tomoki, Suzuki Yuya, Shimoshikiryo Takayuki, Shirai Toshihiro, Itoh Kunihiko

Abstract excerpt

Inflammation decreases the activity of cytochrome P450 3A (CYP3A). Nucleotide-binding oligomerization domain (NOD)-like receptor family pyrin domain containing 3 (NLRP3) is responsible for regulating the inflammatory response, and its genetic polymorphisms have been linked to inflammatory diseases such as asthma. However, there have been few studies on the effect of NLRP3 on CYP3A activity. We aimed to...

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PMID: 38482940
DOI: 10.1002/cpt.3254

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