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PBMC-derived integration-free iPSCs line SDQLCHi039-A from a patient with X-linked agammaglobulinemia carrying a novel 9-bp in-frame deletion in BTK gene.

Stem cell research - 1 Mar 2021

Liu Ning, Yang Xiaomeng, Wang Sulan, Dong Rui, Li Yue, Lv Yuqiang, Liu Yi, Gai Zhongtao

Abstract excerpt

X-linked agammaglobulinemia (XLA, OMIM #300755) is one of the most common pediatric primary immunodeficiencies characterized by failure to produce mature B lymphocytes and hypogammaglobulinemia, caused by mutation of the gene encoding Bruton's tyrosine kinase (BTK, OMIM *300300), a key regulator in B-cell development. Patientssuffering XLA are prone to recurrentbacterial infection. We established an induced...

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PMID: 33453577
DOI: 10.1016/j.scr.2021.102165

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PBMC-derived integration-free iPSCs line SDQLCHi039-A from a patient with X-linked agammaglobulinemia carrying a novel 9-bp in-frame deletion in BTK gene.PMID 33453577Read ↗

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