Article
SEOM clinical guidelines in hereditary breast and ovarian cancer (2019).
Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico - 1 Feb 2020
González-Santiago S, Ramón Y Cajal T, Aguirre E, Alés-Martínez J E, Andrés R, Balmaña J, Graña B, Herrero A, Llort G, González-Del-Alba A
Abstract excerpt
Mutations in BRCA1 and BRCA2 high penetrance genes account for most hereditary breast and ovarian cancer, although other new high-moderate penetrance genes included in multigene panels have increased the genetic diagnosis of hereditary breast and ovarian cancer families by 50%. Multigene cancer panels provide new challenges related to increased frequency of variants of uncertain significance, new gene-specific...
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