Article
The Effect of Micronutrients on Obese Phenotype of Adult Mice Is Dependent on the Experimental Environment.
Nutrients - 29 Feb 2024
Yang Zeyu, Kubant Ruslan, Kranenburg Eva, Cho Clara E, Anderson G Harvey
Abstract excerpt
The environment of the test laboratory affects the reproducibility of treatment effects on physiological phenotypes of rodents and may be attributed to the plasticity of the epigenome due to nutrient-gene-environment interactions. Here, we explored the reproducibility of adding a multi-vitamin-mineral (MVM) mix to a nutrient-balanced high-fat (HF) diet on obesity, insulin resistance (IR), and gene expression in...
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