Article
Intrahepatic IgA complex induces polarization of cancer-associated fibroblasts to matrix phenotypes in the tumor microenvironment of HCC.
Hepatology (Baltimore, Md.) - 1 Nov 2024
Park Jong Geun, Roh Pu Reun, Kang Min Woo, Cho Sung Woo, Hwangbo Suhyun, Jung Hae Deok, Kim Hyun Uk, Kim Ji Hoon, Yoo Jae-Sung, Han Ji Won, Jang Jeong Won, Choi Jong Young, Yoon Seung Kew, You Young Kyoung, Choi Ho Joong, Ryu Jae Yong, Sung Pil Soo
Abstract excerpt
BACKGROUND AND AIMS: Cancer-associated fibroblasts (CAFs) play key roles in the tumor microenvironment. IgA contributes to inflammation and dismantling antitumor immunity in the human liver. In this study, we aimed to elucidate the effects of the IgA complex on CAFs in Pil Soo Sung the tumor microenvironment of HCC. APPROACH AND RESULTS: CAF dynamics in HCC tumor microenvironment were analyzed through single-cell...
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