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Epigenetic effects of paternal environmental exposures and experiences on offspring phenotypes.

Trends in genetics : TIG - 1 Sept 2025

Liao Huan, Lu Da, Reisinger Sonali N, Mehrabadi Mehrshad Rashidi, Gubert Carolina, Hannan Anthony J

Abstract excerpt

Recent decades have revealed increasing evidence for epigenetic inheritance through paternal environmental exposures and experiences, affecting offspring health outcomes across diverse species. Key epigenetic mediators in sperm may include DNA methylation, chromatin modifications, as well as small and long non-coding (nc)RNAs. Identified environmental influences extend beyond lifestyle factors (e.g., exercise,...

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PMID: 40467385
DOI: 10.1016/j.tig.2025.04.015

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