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Epigenetic aging of human blood cells is influenced by the age of the host body

4 Mar 2024

Abstract excerpt

Allogenic hematopoietic stem cell transplantation is a therapeutic procedure performed over a wide range of donor and recipient age combinations, representing natural experiments of how the age of the recipient affects aging in transplanted donor cells in vivo. We measured DNA methylation and epigenetic aging in donors and recipients and found that biological epigenetic clocks are accelerated in cells...

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PMID: 38439206
DOI: 10.1111/acel.14112

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