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Article

Host range expansion of Acinetobacter phage vB_Ab4_Hep4 driven by a spontaneous tail tubular mutation.

Frontiers in cellular and infection microbiology - 1 Jan 2024

He Penggang, Cao Feng, Qu Qianyu, Geng Huaixin, Yang Xin, Xu Tong, Wang Rui, Jia Xu, Lu Mao, Zeng Peibin, Luan Guangxin

Abstract excerpt

Bacteriophages (phages) represent promising alternative treatments against multidrug-resistant Acinetobacter baumannii (MDRAB) infections. The application of phages as antibacterial agents is limited by their generally narrow host ranges, so changing or expanding the host ranges of phages is beneficial for phage therapy. Multiple studies have identified that phage tail fiber protein mediates the recognition and...

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Identifiers

PMID: 38435308
DOI: 10.3389/fcimb.2024.1301089
PMCID: PMC10904470

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