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Article

Identification of a novel mutation of Platelet-Derived Growth Factor-C (PDGFC) gene in a girl with Non-Syndromic cleft lip and palate.

Gene - 5 Jun 2024

Rahnama Maryam, Movahedi Tahereh, Eslahi Atieh, Kaseb-Mojaver Nasrin, Alerasool Masoome, Adabi Nasim, Mojarrad Majid

Abstract excerpt

BACKGROUND: Cleft lip with or without cleft palate (CL/CP) is a prevalent congenital malformation. Approximately 16 candidate loci for CL/CP have been identified in both animal models and humans through association or genetic linkage studies. One of these loci is the platelet-derived growth factor-C (PDGFC) gene. In animal models, a mutation in the PDGFC gene has been shown to lead to CL/CP, with PDGF-C protein...

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Identifiers

PMID: 38432532
DOI: 10.1016/j.gene.2024.148335

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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