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Article

Early-life nasal microbiota dynamics relate to longitudinal respiratory phenotypes in urban children.

The Journal of allergy and clinical immunology - 1 Jun 2024

McCauley Kathryn E, Durack Juliana, Lynch Kole V, Fadrosh Douglas W, Fujimura Kei E, Vundla Faith, Özçam Mustafa, LeBeau Petra, Caltroni Agustin, Burns Preston, Tran Hoang T, Bacharier Leonard B, Kattan Meyer, O'Connor George T, Wood Robert A, Togias Alkis, Boushey Homer A, Jackson Daniel J, Gern James E, Lynch Susan V

Abstract excerpt

BACKGROUND: Five distinct respiratory phenotypes based on latent classes of longitudinal patterns of wheezing, allergic sensitization. and pulmonary function measured in urban children from ages from 0 to 7 years have previously been described. OBJECTIVE: Our aim was to determine whether distinct respiratory phenotypes are associated with early-life upper respiratory microbiota development and environmental...

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Identifiers

PMID: 38423369
DOI: 10.1016/j.jaci.2023.12.032
PMCID: PMC11162315

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