Article

Dynamics of the upper airway microbiome in the pathogenesis of asthma-associated persistent wheeze in preschool children

2017-11-20

Abstract excerpt

<h4>ABSTRACT</h4> Repeated cycles of infection-associated lower airway inflammation drives the pathogenesis of persistent wheezing disease in children. Tracking these events across a birth cohort during their first five years, we demonstrate that >80% of infectious events indeed involve viral pathogens, but are accompanied by a shift in the nasopharyngeal microbiome (NPM) towards dominance by a small range of pat...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 68833cbb-a981-5c45-b2c7-66d4e62473dd
DOI: 10.1101/222190

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Dynamics of the upper airway microbiome in the pathogenesis of asthma-associated persistent wheeze in preschool childrenDOI 10.1101/222190Read

Understanding respiratory microbiome–immune system interactions in health and diseaseSemantic proximity Read

Microbial influencers: the airway microbiome’s role in asthmaSemantic proximity Read

The airway microbiota of neonates colonized with asthma-associated pathogenic bacteriaSemantic proximity Read

Culture and molecular-based profiles show shifts in bacterial communities of the upper respiratory tract that occur with ageSemantic proximity Read

Early-preschool wheeze trajectories are predominantly nonallergic with distinct biologic and microbiome traitsSemantic proximity Read

The microbiome in asthmaSemantic proximity Read

Microbiome and Asthma: Microbial Dysbiosis and the Origins, Phenotypes, Persistence, and Severity of Asthma.Semantic proximity Read

[Recent research on the relationship between pulmonary microbiome and asthma endotypes in children].Semantic proximity Read

The infant gut virome is associated with preschool asthma risk independently of bacteriaSemantic proximity Read

Synergy of Atopy and Airway Dysbiosis Promotes IL-5 Expression and Asthma Persistence in ChildrenSemantic proximity Read

Pediatric asthma comprises different phenotypic clusters with unique nasal microbiotasSemantic proximity Read

Nasopharyngeal Dysbiosis Precedes the Development of Lower Respiratory Tract Infections in Young Infants, a Longitudinal Infant Cohort StudySemantic proximity Read