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Article

Virulence Inhibitors from Brazilian Peppertree Block Quorum Sensing and Abate Dermonecrosis in Skin Infection Models.

Scientific reports - 10 Feb 2017

Muhs Amelia, Lyles James T, Parlet Corey P, Nelson Kate, Kavanaugh Jeffery S, Horswill Alexander R, Quave Cassandra L

Abstract excerpt

Widespread antibiotic resistance is on the rise and current therapies are becoming increasingly limited in both scope and efficacy. Methicillin-resistant Staphylococcus aureus (MRSA) represents a major contributor to this trend. Quorum sensing controlled virulence factors include secreted toxins responsible for extensive damage to host tissues and evasion of the immune system response; they are major contributors...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 28186134
DOI: 10.1038/srep42275
PMCID: PMC5301492

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