Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Variant functional assessment in Drosophila by overexpression: what can we learn?

Genome - 1 Jun 2024

Her Yina, Pascual Danielle M, Goldstone-Joubert Zoe, Marcogliese Paul C

Abstract excerpt

The last decade has been highlighted by the increased use of next-generation DNA sequencing technology to identify novel human disease genes. A critical downstream part of this process is assigning function to a candidate gene variant. Functional studies in Drosophila melanogaster, the common fruit fly, have made a prominent contribution in annotating variant impact in an in vivo system. The use of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Drosophila Proteins
Share to Genetic Variation
Share to Genetic Neurodegenerative Diseases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cardiomyopathy and Myosin Studies

Share to Drosophila melanogaster

Share to Mitochondrial Function and Pathology

Source

Identifiers

PMID: 38412472
DOI: 10.1139/gen-2023-0135

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Variant functional assessment in Drosophila by overexpression: what can we learn?PMID 38412472Read ↗

Functional assays in Drosophila facilitate classification of variants of uncertain significance associated with rare diseases.Semantic proximity Read ↗

An <i>in vivo</i> platform to identify pathogenic lociSemantic proximity Read ↗

Inter-Species Rescue of Mutant Phenotype-The Standard for Genetic Analysis of Human Genetic Disorders in Drosophila melanogaster Model.Semantic proximity Read ↗

From variant to function in human disease genetics.Semantic proximity Read ↗

Etiology of Human Genetic Disease on the Fly.Semantic proximity Read ↗

Functional genomics in Drosophila models of human disease.Semantic proximity Read ↗

Recent Developments in Using <em>Drosophila</em> as a Model for Human Genetic DiseaseSemantic proximity Read ↗

Functional Studies of Genetic Variants Associated with Human Diseases in Notch Signaling-Related Genes Using Drosophila.Semantic proximity Read ↗

Sentinel interaction mapping - a generic approach for the functional analysis of human disease gene variants using yeast.Semantic proximity Read ↗

Comprehensive In Vivo Interrogation Reveals Phenotypic Impact of Human Enhancer Variants.Semantic proximity Read ↗

Sentinel Interaction Mapping (SIM) – A generic approach for the functional analysis of human disease gene variants using yeastSemantic proximity Read ↗

The hitchhiker's guide to Xenopus genetics.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.