Article
Ventilatory capacity in CLAD is driven by dysfunctional airway structure.
EBioMedicine - 1 Mar 2024
Kerckhof Pieterjan, Ambrocio Gene P L, Beeckmans Hanne, Kaes Janne, Geudens Vincent, Bos Saskia, Willems Lynn, Vermaut Astrid, Vermant Marie, Goos Tinne, De Fays Charlotte, Aversa Lucia, Mohamady Yousry, Vanstapel Arno, Orlitová Michaela, Van Slambrouck Jan, Jin Xin, Varghese Vimi, Josipovic Iván, Boone Matthieu N, Dupont Lieven J, Weynand Birgit, Dubbeldam Adriana, Van Raemdonck Dirk E, Ceulemans Laurens J, Gayan-Ramirez Ghislaine, De Sadeleer Laurens J, McDonough John E, Vanaudenaerde Bart M, Vos Robin
Abstract excerpt
BACKGROUND: Chronic lung allograft dysfunction (CLAD) encompasses three main phenotypes: bronchiolitis obliterans syndrome (BOS), restrictive allograft syndrome (RAS) and a Mixed phenotype combining both pathologies. How the airway structure in its entirety is affected in these phenotypes is still poorly understood. METHODS: A detailed analysis of airway morphometry was applied to gain insights on the effects of...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.