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Beyond the promise: evaluating and mitigating off-target effects in CRISPR gene editing for safer therapeutics

18 Jan 2024

Abstract excerpt

Over the last decade, CRISPR has revolutionized drug development due to its potential to cure genetic diseases that currently do not have any treatment. CRISPR was adapted from bacteria for gene editing in human cells in 2012 and, remarkably, only 11 years later has seen it's very first approval as a medicine for the treatment of sickle cell disease and transfusion-dependent beta-thalassemia. However, the...

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PMID: 38390600
DOI: 10.3389/fbioe.2023.1339189

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