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Article

Mechanisms of cerebral venous sinus thrombosis due to essential thrombocythemia: Current status and future perspectives.

Thrombosis research - 1 Mar 2026

Liu Zexun, Xiang Yuanyuan, Xie Changlin, Yin Xiaoping, Zhang Manqing, Chen Zhiying

Abstract excerpt

Essential Thrombocythemia (ET) is a myeloproliferative neoplasm driven by JAK2V617F, CALR, and MPL mutations, characterized by persistent thrombocytosis and hypercoagulability. Cerebral Venous Sinus Thrombosis (CVST) represents a severe complication of ET, yet the underlying mechanisms remain unclear. Genetically, the JAK2V617F mutation activates the JAK-STAT pathway, inducing platelet hyperactivation, neutrophil...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 41691901
DOI: 10.1016/j.thromres.2026.109613

Genes

CALR
MPL
JAK2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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