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Ubiquitin Ligase Parkin Regulates the Stability of SARS-CoV-2 Main Protease and Suppresses Viral Replication

22 Feb 2024

Abstract excerpt

High Resolution Image Download MS PowerPoint Slide The highly infectious coronavirus SARS-CoV-2 relies on the viral main protease (M pro, also known as 3CLpro or Nsp5) to proteolytically process the polyproteins encoded by the viral genome for the release of functional units in the host cells to initiate viral replication. M pro also interacts with host proteins of the innate immune pathways, such as IRF3 and...

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PMID: 38386664
DOI: 10.1021/acsinfecdis.3c00418

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