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Article

Aberrant miR-29 is a predictive feature of severe phenotypes in pediatric Crohn's disease.

JCI insight - 22 Feb 2024

Shumway Alexandria J, Shanahan Michael T, Hollville Emilie, Chen Kevin, Beasley Caroline, Villanueva Jonathan W, Albert Sara, Lian Grace, Cure Moises R, Schaner Matthew, Zhu Lee-Ching, Bantumilli Surekha, Deshmukh Mohanish, Furey Terrence S, Sheikh Shehzad Z, Sethupathy Praveen

Abstract excerpt

Crohn's disease (CD) is a chronic inflammatory gut disorder. Molecular mechanisms underlying the clinical heterogeneity of CD remain poorly understood. MicroRNAs (miRNAs) are important regulators of gut physiology, and several have been implicated in the pathogenesis of adult CD. However, there is a dearth of large-scale miRNA studies for pediatric CD. We hypothesized that specific miRNAs uniquely mark pediatric...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 38385744
DOI: 10.1172/jci.insight.168800
PMCID: PMC10967384

Genes

PMP22

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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