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Short Ileal Microvillus Length Phenotype Associates with Progression from Inflammatory to Complicated Disease Behavior in Pediatric Crohn's Disease.

Inflammatory bowel diseases - 1 Feb 2026

Haberman Yael, Braun Tzipi, Karns Rebekah, Bartel Courtney A, Bonkowski Erin, Simpson Katherine F, Walters Thomas D, Hyams Jeffrey S, Liu Ta-Chiang, Kugathasan Subra, Denson Lee A, VanDussen Kelli L

Abstract excerpt

BACKGROUND AND AIMS: Our previous studies of adult Crohn's disease (CD) suggested ileal microvillus length (MVL) as a prognostic biomarker for therapy response. We investigated if ileal MVL also differed in pediatric CD versus controls and tested for associations with stricturing or penetrating disease behavior outcomes. METHODS: We determined the average ileal MVL of 412 CD and 88 control H&E-stained ileal...

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Biomarkers
Case-Control Studies
Child
Crohn Disease
Disease Progression

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PMID: 41309136
DOI: 10.1093/ibd/izaf288
PMCID: PMC12695081

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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