Article
Low Serum Levels of MicroRNA-19 Are Associated with a Stricturing Crohn's Disease Phenotype.
Inflammatory bowel diseases - 1 Aug 2015
Lewis Amy, Mehta Shameer, Hanna Luke N, Rogalski Laura A, Jeffery Rosemary, Nijhuis Anke, Kumagai Tomoko, Biancheri Paolo, Bundy Jake G, Bishop Cleo L, Feakins Roger, Di Sabatino Antonio, Lee James C, Lindsay James O, Silver Andrew
Abstract excerpt
BACKGROUND: Development of fibrosis and subsequent stricture formation in Crohn's disease (CD) increases morbidity and rates of surgery and reduces patients' quality of life. There are currently no biomarkers of intestinal fibrosis that might allow earlier identification and better management of patients at increased risk of stricture formation. METHODS: MicroRNA profiling of serum from CD patients was used to...
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