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The Role of miR-29a and miR-143 on the Anti-apoptotic MCL-1/cIAP-2 Genes Expression in EGFR Mutated Non-small Cell Lung Carcinoma Patients.

Biochemical genetics - 1 Dec 2024

Abrehdari-Tafreshi Zahra, Arefian Ehsan, Rakhshani Nasser, Najafi S Mahmoud A

Abstract excerpt

The survival rate of lung cancer is low due to the high frequency of drug resistance in patients with mutations in the driver genes. Overexpression of anti-apoptotic genes is one of the most prominent features of tumor drug resistance. EGFR signaling induces the expression of anti-apoptotic genes. Also, microRNAs (miRNAs) have a critical role in regulating biological functions such as apoptosis; a process mostly...

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PMID: 38379036
DOI: 10.1007/s10528-024-10740-6

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