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Article

An integrated genome-wide approach to discover deregulated microRNAs in non-small cell lung cancer: Clinical significance of miR-23b-3p deregulation.

Scientific reports - 28 Aug 2015

Begum Shahnaz, Hayashi Masamichi, Ogawa Takenori, Jabboure Fayez J, Brait Mariana, Izumchenko Evgeny, Tabak Sarit, Ahrendt Steven A, Westra William H, Koch Wayne, Sidransky David, Hoque Mohammad O

Abstract excerpt

In spite of significant technical advances, genesis and progression of non-small cell lung cancer (NSCLC) remain poorly understood. We undertook an integrated genetic approach to discover novel microRNAs that were deregulated in NSCLCs. A total 119 primary NSCLCs with matched normal were analyzed for genome-wide copy number changes. We also tested a subset of matched samples by microRNA expression array, and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 26314549
DOI: 10.1038/srep13236
PMCID: PMC4551983

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