Article
MiR-200c-3p suppression is associated with development of acquired resistance to epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors in EGFR mutant non-small cell lung cancer via a mediating epithelial-to-mesenchymal transition (EMT) process.
Cancer biomarkers : section A of Disease markers - 1 Jan 2020
Wang Hsin-Yi, Liu Yi-Nan, Wu Shang-Gin, Hsu Chia-Lang, Chang Tzu-Hua, Tsai Meng-Feng, Lin Yen-Ting, Shih Jin-Yuan
Abstract excerpt
BACKGROUND: EGFR-mutant lung cancer inevitably develops resistance to epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs). OBJECTIVE: To investigate the clinical relevance of microRNAs (miRNAs) in TKI therapy response and resistance. METHODS: We performed a miRNA PCR array analysis and used The Cancer Genome Atlas (TCGA) database to identify potential miRNAs related to EGFR TKIs resistance....
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