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Article

Translational insights and overall survival in the U31402-A-U102 study of patritumab deruxtecan (HER3-DXd) in EGFR-mutated NSCLC.

Annals of oncology : official journal of the European Society for Medical Oncology - 1 May 2024

Yu H A, Baik C, Kim D-W, Johnson M L, Hayashi H, Nishio M, Yang J C-H, Su W-C, Gold K A, Koczywas M, Smit E F, Steuer C E, Felip E, Murakami H, Kim S-W, Su X, Sato S, Fan P-D, Fujimura M, Tanaka Y, Patel P, Sternberg D W, Sellami D, Jänne P A

Abstract excerpt

BACKGROUND: Human epidermal growth factor receptor 3 (HER3) is broadly expressed in non-small-cell lung cancer (NSCLC) and is the target of patritumab deruxtecan (HER3-DXd), an antibody-drug conjugate consisting of a HER3 antibody attached to a topoisomerase I inhibitor payload via a tetrapeptide-based cleavable linker. U31402-A-U102 is an ongoing phase I study of HER3-DXd in patients with advanced NSCLC....

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Identifiers

PMID: 38369013
DOI: 10.1016/j.annonc.2024.02.003

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EGFR
ERBB3
TOP1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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